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. 2024 Oct 30;25(21):11689. doi: 10.3390/ijms252111689

Figure 3.

Figure 3

Treatment with AAC2 and INS altered brain mass and composition, respectively, without affecting body composition. Differences in body composition were measured in living WT (n = 6) and APP/PS1 mice (C, n = 6; A, n = 8; I, n = 4; A+I, n = 7) by EchoMRI: (a–c) The total body mass (a), body lean mass (b), and body fat mass (c) in of WT and APP/PS1 mice. Asterisks, comparison between WT and APP/PS1 mice: * p < 0.05, ** p < 0.01, *** p < 0.001. ANOVA (d–f) Body composition (d), lean (e), and fat (f) composition percentage were calculated taking into account mass of each animal. Asterisk, comparison between control and treated groups, * p < 0.05. ANOVA (g–i) Differences in brain composition were measured in frozen brains from same mouse groups by EchoMRI. The total brain mass (g), brain lean mass (h), and brain fat mass (i) of WT and APP/PS1 mice. Asterisk, * p < 0.05. ANOVA (j–l) The brain composition (% compared to mass of each animal) (j), brain lean (k), and brain fat compositions (%) (l) of WT and APP/PS1 mice. Asterisk, * p < 0.05. ANOVA.