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. 2024 Oct 30;25(21):11689. doi: 10.3390/ijms252111689

Figure 7.

Figure 7

Different responses of APP/PS1 mice to AAC2 and hINS result from the possible disbalance of GABAergic synaptic excitation and inhibition (a–d) The expression of cerebral Syp (a) Syn2 (b), as well as implicated in excitation Bdnf (c), Slc6a1 (d) in WT (n = 5) and APP/PS1 mice (C, n = 5; A, n = 7; I, n = 4; A+I, n = 6). Differential analysis was performed using DESeq2 R package mainly based on the GLM and empirical Bayes shrinkage, * p < 0.05, ** p < 0.01, *** p < 0.001. (e) Hypothesized mechanism for discrepant effects of AAC2 and INS treatment in APP/PS1 mice.