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Schematic representation of the process leading to neurofibrillar tangle (NFT) formation in Alzheimer’s disease. Under physiological conditions, tau functions as a microtubule-associated protein. Pathological tau, prone to aggregation, undergoes hyper-phosphorylation, resulting in destabilization and dissociation of microtubules. Subsequently, soluble phosphorylated tau molecules aggregate to form NFTs. NFTs, Neurofibrillary tangles.
