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. 2024 Oct 26;13(21):6428. doi: 10.3390/jcm13216428

Table 1.

Studies included in the systematic review.

Author Year Age (Years) Sex Etiology Imaging Complication Surgery Treatment Culture
Adnani et al. [7] 2023 8 F ARS ce-CT PSC NA NA NA
Allfather et al. [8] 2017 7 F FARS ce-CT EDA ESS, CRA MER, VAN Staphylococcus, Fusobacterium
AlMoosa et al. [9] 2016 9 F T ce-CT, ce-MRI None ESS, CRA empirical: CLI, CEF; AC: VOR Aspergillus Fumigatus
Amstrup et al. [10] 2023 9 M ARS ce-CT, ce-MRI SSST, EDA None CEF, MET S. anginosus
Arnold et al. [11] 2009 10 M T CT EDA EXD, CRE CEF, VAN, MET S. intermedius
Arora et al. [12] 2014 14 M FARS ce-CT None EXD CEF, CLI NA
Avcu et al. [13] 2015 12 M ARS ce-CT, ce-MRI PSC EXD, ESS CEF, VAN, MET NA
Bağdatoğlu et al. [14] 2001 18 M ARS ce-CT EDA, SDA CRA empirical: IM gentamycin
AC: VAN, RIF, MET
STE
Bambakidis et al. [15] 2001 11 M ARS CT, only 2 pts MRI SDA, OA CRA BSATB Fusobacterium,
S. pneumoniae
11 M ARS EDA, SDA CRA BSATB S. milleri
16 M ARS SDA EXD, CRA BSATB Klebsiella sp., Peptostreptococcus
18 M ARS EDA EXD, CRA BSATB S. microaerophilic
15 M ARS EDA CRA BSATB Peptostreptococcus
14 M ARS EDA CRA BSATB S. viridans
11 F ARS EDA, SDA, BA CRA BSATB S. pyogenes
Behbahani et al. [3] 2020 7 M ARS ce-CT or ce-MRI EDA ESS, CRA CEF S. pyogenes, Corynebacterium, Pseudodiphtheriticum
13 M ARS SDA ESS, CRA CEF, MET S. anginosus
14 M ARS EDA ESS, CRA CEF, MET S. intermedius
6 M ARS EDA ESS, CRA CEF S. pyogenes
12 M ARS EDA, SDA ESS, CRA CEF, CLI S. anginosus
14 M ARS CER ESS, CRA CEF, MET S. anginosus, S. intermedius, Staph. epidermidis
13 M ARS EDA ESS, CRA CEF, MET S. intermedius
10 F ARS EDA, CER ESS, CRA CEF, MET S. intermedius
11 M ARS EDA ESS CEF, MET Staph epidermidis, Propionibacterium,
Avidum Diphtheroids
5 M ARS CER ESS CEF, MET S. pyogenes
5 F ARS EDA, MEN ESS CEF, MET S. intermedius
12 M ARS SDA ESS, CRA CEF, MET S, intermedius, Staph. aureus, Staph. epidermidis
Belharti et al. [16] 2023 15 M FARS ce-CT EDA NA NA NA
Bhalla et al. [17] 2016 5 M ARS ce-CT subperiosteal OA, EDA ESS CEF, CLI, MET NA
Blackman et al. [18] 2005 9 M ARS ce-CT OC EXD CEF, VAN, MET Staph. saccharolyticus
Blumfield et al. [19] 2011 9–16 8M
1F
ARS 8 ce-CT, 1 ce-MRI 2 SSST
6 EDA
1 SDA
3: EXD, ESS, CRA
2: ESS, 2: EXD, CRE
1: none, 1: transferred to another hospital
BSATB S. milleri, S. pneumonia,
S. group F, Staph. aureus
Butskiy et al. [20] 2017 10 M ARS ce-CT None EXD CEF, CLI S. intermedius
Cannon et al. [21] 2017 5 M ARS ce-MRI None EXD NA S. anginosus
Cheng et al. [22] 2009 32 months M SEP ce-CT SSST EXD CLI Staph. aureus
Costa et al. [23] 2020 13 M ARS ce-CT BA, OA EXD, ESS, CRA CEF, VAN, MET NA
Davidson et al. [24] 2006 14 F ARS ce-CT EDA, fistula CRE NA NA
Dayan et al. [25] 2020 4 F ARS ce-CT None EXD BSATB NA
Durur-Subasi et al. [26] 2008 14 F ARS ce-CT EDA, BA EXD NA NA
Faridi et al. [27] 2022 4 F ARS ce-CT, ce-MRI CER EXD CEF, VAN NA
Feder et al. [28] 1987 6 F ARS X-ray, ce-CT None ESS empirical: cefuroxime and gentamicin; AC: CLI Peptostreptococcus,
Bacteroides melaninogenicus
12 F ARS ce-CT EDA ESS, CRA empirical: CLI
AC: penicillin
Alpha Hemolytic S.
Forgie et al. [29] 2008 16 M ARS NA None EXD BSATB NA
Fu B. [30] 2010 16 M FARS ce-CT None EXD BSATB NA
Fullerton et al. [31] 2016 11 M FARS ce-MRI EDA EXD, ESS, CRA CEF S. pyogenes
Gildener-Leapman et al. [32] 2012 5 M FARS ce-CT EDA, SDA, CER EXD, ESS, CRA CEF, VAN, MET S. intermedius
Gozgec et al. [33] 2022 15 M ARS ce-CT OC EXD BSATB NA
Guillén et al. [34] 2001 12 F ARS ce-CT OC, EDA, SDA CRA CEF, VAN, MET NA
Gupta et al. [35] 2004 3 M FARS ce-CT, ce-MRI EDA ESS, CRA CEF, MET, cloxacillin STE
Haider et al. [36] 2012 14 M ARS ce-CT, ce-MRI MEN, SDA EXD, ESS, CRA MER, MET F. necrophorum
Hassan et al. [37] 2020 15 M T ce-CT, ce-MRI EDA EXD, ESS empirical: VAN, AMPS
AC: CEF, MET
F. nucleatum
Hayek et al. [38] 2007 9 M ARS ce-CT PSC EXD, ESS AMPS, then CEF NA
Heale et al. [39] 2015 5 F NA ce-CT PSC, EDA EXD, CRA CEF, ET S. anginosus
Hicks et al. [40] 2011 NA NA ARS ce-CT, MRI EDA, OC ESS BSATB S. milleri
NA NA ARS ce-CT, MRI EDA. SDA, SSST EXD, ESS BSATB S. milleri
NA NA ARS ce-CT SDA ESS, CRA BSATB S. milleri
NA NA ARS ce-CT, MRI EDA, SDA ESS, CRA BSATB Cutibacterium acnes
NA NA ARS ce-CT, MRI SDA EXD, ESS BSATB NA
NA NA ARS ce-CT BA CRA BSATB S. milleri
Hitti et al. [41] 2010 6 F ARS ce-CT EDA ESS, CRE empirical: CEF, VAN, MET
AC: AMPS
S. pyogenes
Holder et al. [42] 1991 17 M ARS X-ray, ce-CT BA ESS empirical: ceftazidime and MET
AC: ceftazidime, MET, penicillin, chloramphenicol
Non-hemolytic S.
Hore et al. [43] 2000 12 F ARS CT None EXD, ESS CEF, MET S. milleri
Huijssoon et al. [44] 2003 8 M ARS ce-CT OC EXD BSATB S. milleri
Ikoma et al. [45] 2020 12 M FARS ce-CT, ce-MRI EDA, PNC EXD, CRA MER, VAN then CEF, MET S. constellatus
Is et al. [46] 2007 11 F NA ce-CT EDA EXD AMP, CEF, MET Peptostreptococcus, Veillonella, E. Coli
Jafri et al. [47] 2015 11 F ARS ce-CT EDA EXD, CRA AMO S. intermedius
Joo et al. [48] 2019 7 F FARS ce-CT OC EXD AMPS NA
Kalkan et al. [49] 2017 14 M ARS ce-CT, ce-MRI EDA ESS, CRA BSATB STE
Karadaghy et al. [50] 2022 23 months M ARS ce-CT PSC EXD, ESS AMPS, then LEV S. intermedius, Granulicatella adiacens
Karaman et al. [51] 2008 7 F ARS ce-CT None EXD, ESS AMPS S. milleri
Ketenci et al. [52] 2011 12 F ARS ce-CT SDA, BA EXD, ESS, CRA AMPS, VAN, MET Peptostreptococcus
13 M ARS ce-CT SDA, BA EXD, ESS, CRA CEF, AMPS, MET S. pyogenes
Khan et al. [53] 2006 10 F MAS ce-CT EDA EXD, CRA, Cortical Mastoidectomy CEF, CLI STE
Kim et al. [54] 2012 18 M ARS ce-MRI EDA, SDA EXD, CRA AMO, then VAN, ceftazidime, MET STE
Klivitsky et al. [55] 2023 11 M ARS ce-CT, ce-MRI PSC, SSST, CST EXT, CRA CEF and MET S. pneumoniae
9 F ARS CT, MRI None EXD CEF and CLI Negative
12 F ARS ce-CT, MRI EDA, SSST EXD, ESS, CRA CEF and MET S. constellatus
14 M ARS CT, ce-CT, MRI EDA, BA ESS CEF and MET S. intermedius
15 M ARS CT, ce-CT, MRI EDA EXD, ESS, CRA CEF and MET STE
13 M ARS CT, ce-CT, MRI EDA ESS CEF and MET Prevotella
17 F ARS CT None ESS CEF and CLI S. pneumoniae
14 M ARS CT, MRI EDA EXD, ESS, CRA CEF and MET STE
10 F ARS CT EDA EXD CEF and MET STE
9 M ARS CT PSC EXXD cefuroxime and MET Staph. aureus
Kombogiorgas et al. [2] 2006 11 M ARS ce-MRI EDA EXD, ESS, CRA CEF, MET STE
Kuhar et al. [56] 2023 3 F ARS ce-CT, ce-MRI OC, EDA, SSST EXD, ESS, CRA CEF S. intermedius
Kühn et al. [57] 2022 6 M FARS ce-CT, ce-MRI SDA, MEN, CER ESS, CRA cefotaxime, CLI S. intermedius
17 M ARS ce-CT, ce-MRI EDA ESS CEF NA
9 F ARS ce-CT, ce-MRI EDA ESS, CRA cefotaxime, CLI S. intermedius
Lang et al. [58] 2001 14 F FARS ce-CT SDA, SSST EXD, CRA cephalosporin, MET STE
15 F ARS ce-CT SDA, SSST EXD, CRA cephalosporin, MET S. pyogenes
12 F ARS ce-CT EDA, SDA EXD, ESS, CRA cephalosporin, MET H. influenzae
Lauria et al. [59] 2014 14 M FARS ce-CT None EXD, ESS VAN, MET, ceftazidime, then AMPS S. constellatus
Ling et al. [60] 2021 9 M ARS ce-RM EDA NA BSATB NA
Linton et al. [61] 2019 16 M T ce-CT OA EXD, ESS AMOC MET STE
Liu et al. [62] 2015 10 F ARS ce-CT EDA ESS, CRA MER, then cephalexin Alpha Hemolytic S.
Maheshwar et al. [63] 2001 14 M T ce-CT None ESS AMOC, then flucloxacillin, fusidic acid, MET, RIF S. intermedius
Marzuillo et al. [64] 2017 9 F ARS ce-CT Fistula NA AMOC NA
McGee et al. [65] 2022 NA M ARS ce-CT None EXD, ESS CEF, MET Staph. aureus
Morley et al. [66] 2009 7 M ARS ce-CT, ce-MRI EDA CRA benzylpenicillin, flucloxacillin then CLI NA
Moser et al. [67] 2009 14 F ARS ce-CT EDA EXD, ESS CEF STE
Moses et al. [68] 2018 15 M FB ce-CT SDA ESS, CRA empirical: TAZO
AC: MER, MET
F. necrophorum
Nastovska et al. [69] 2017 15 M FARS ce-MRI None ESS, CRA benzylpenicillin S. anginosus
Nicoli et al. [70] 2014 13 M FARS ce-CT, ce-MRI EDA ESS, CRA BSATB S. intermedius
Nourkami-Tutdibi et al. [71] 2020 6 M FARS ce-CT, ce-MRI EDA CRA sultamicillin, then cefotaxime, CLI S. intermedius
Olmaz et al. [72] 2019 12 M ARS CT- ce-MRI EDA CRA CEF, VAN, MET NA
Onesimo et al. [73] 2011 8 F ARS ce-MRI EDA NA NA S. intermedius
Özkaya Parlakay et al. [74] 2012 13 M ARS ce-CT None None cefotaxime and VAN NA
Öztürk et al. [75] 2020 15 M FARS ce-CT None NA CEF and teicoplanin NA
Palabiyik et al. [76] 2016 18 M ARS ce-CT, ce-MRI PSC ESS AMPS, MET, or CEF 1 E. Coli,
1 S. Epidermidis,
6 STE
17 M ARS ce-CT, ce-MRI None ESS
9 M ARS ce-CT, ce-MRI EDA EXD, CRA
11 F ARS ce-CT, ce-MRI EDA ESS, CRA
7 M T ce-CT, ce-MRI None ESS
17 M ARS ce-CT, ce-MRI None EXD
Palacios-García et al. [77] 2019 15 M ARS ce-CT None EXD, ESS empirical: CLI
AC: LEV
S. intermedius
Parida et al. [78] 2012 10 M ARS ce-CT PSC EXD, ESS BSATB Staph. aureus
15 F CRS ce-CT None EXD, ESS BSATB STE
9 F ARS ce-CT None ESS BSATB STE
11 M T ce-CT None EXD BSATB Pseudomonas aeruginosa
13 M ARS ce-CT None ESS BSATB STE
Patel et al. [79] 2021 13 M SD ce-CT MEN ESS CEF, VAN, MET NA
Patel et al. [80] 2011 11 M ARS ce-CT, ce-MRI fistula, MEN EXD, CRE empirical: AMOC
AC: MER, amphotericin B, then fluconazole
Candida parapsilosis
Pender [81] 1990 13 M ARS CT None ESS oxacillin and ampicillin Staph. aureus, S-viridans
17 M I CT EDA and OA ESS cefuroxime and MET Coagulase neg Staph.
Podolsky-Gondim et al. [82] 2018 14 M ARS ce-CT, ce-MRI EDA EXD, CRA CEF, oxacillin, MET Peptostreptococcus
Przybysz et al. [83] 2018 8 F ARS CT None NA NA NA
Queen et al. [84] 2001 14 M ARS CT, MRI SDA EXD, ESS, CRE BSATB NA
Reddan et al. [85] 2018 6 M ARS CT None ESS NA NA
Rogers [86] 1949 11 M NA NA NA EXD, CRE NA B. Alkaligenes faecalis
16 M NA NA NA EXD, CRE NA STE
Rogo et al. [87] 2013 5 F ARS CT EDA None MER and VAN NA
Russ et al. [88] 2022 11 M I ce-CT EDA ESS, CRA CEF, VAN, MET S. anginosus
Sabatiello et al. [89] 2010 15 M ARS ce-CT SDA, BA NA cefotaxime, CLI Peptostreptococcus, Fusobacterium
Sade et al. [90] 2016 12 M FARS ce-MRI BA NA NA NA
Salomão et al. [91] 2014 11 F CRS ce-CT EDA EXD, CRA BSATB STE
9 M CRS ce-CT EDA None BSATB S. aureus
14 M FARS ce-CT EDA, SDA EXD, CRA BSATB S. pyogenes
12 M T ce-CT EDA EXD, CRA BSATB S. pyogenes
12 M CRS ce-CT EDA EXD, CRA BSATB STE
13 M T ce-CT EDA, fistula EXD, CRA BSATB STE
Sharma et al. [4] 2017 8 F FARS CT, ce-MRI EDA ESS, CRA BSATB S. intermedius
Shehu et al. [92] 2008 10 F ARS CT SDA EXD, CRA BSATB NA
Shemesh et al. [93] 2015 11 M NA ce-CT None NA NA NA
Sheth et al. [94] 2018 15 M FB ce-CT SDA ESS, CRA empirical: CEF, VAN, TAZO
AC: MER, MET
F. necrophorum
17 M FARS ce-CT, ce-MRI SDA, SSST CRA CEF, CLI, VAN F. necrophorum
14 M ARS ce-CT EDA, PNC, CER CRA CEF, VAN, MET F. necrophorum, S. constellatum
Silva et al. [95] 2022 16 F ARS CT, ce-MRI SDA, BA CRA CEF, MET None
Stark et al. [96] 2016 14 M FARS ce-CT None EXD, ESS empirical: flucloxacillin
AC: CLI, RIF
Staph. aureus
Stoddard et al. [97] 2019 13 M FARS ce-MRI EDA CRA CEF, VAN, MET Staph. aureus
Strony et al. [98] 2007 4 M ARS ce-CT EDA EXD, CRA CEF, VAN, MET S. viridans
Sugiyama et al. [99] 2016 17 M ARS ce-CT, ce-MRI EDA, PNC EXD, ESS CEF, MET Peptostreptococcus, Collinsella aerofaciens, Staph. lugdunensis
Suwan et al. [100] 2012 8 F ARS CT EDA EXD, ESS, CRE VAN, cefotaxime, MET, then AMPS S. constellatus, F. necrophorum
Tibesar et al. [101] 2021 15 M ARS ce-CT PSC EXD, ESS CEF, VAN, MET S. intermedius
Tsai et al. [102] 2010 14 M ARS ce-CT SSST EXD, ESS, CRA BSATB F. nucleatum
13 M T ce-CT SDA, BA CRA BSATB Veillonella sp., Peptostreptococcus micros, F. nucleatum, S. viridans, Eikenella corrodens
15 M CRS ce-CT SDA EXD, ESS, CRA BSATB Peptostreptococcus micros; Coagulase neg Staph.
12 M CRS ce-CT SDA ESS, CRA BSATB Coagulase neg Staph., Prevotella sp.
9 F AP ce-CT SDA CRE, fistula repair BSATB P. aeruginosa
13 M ARS ce-CT EDA, PNC, SDA EXD, ESS, CRA CEF, VAN, then penicillin G S. constellatus, Beta-hemolytic non-group A streptococci
Tudor et al. [103] 1981 16 M T CT EDA EXD, CRA nafcillin, gentamicin, then AMO NA
Urík et al. [104] 2015 6 M ARS ce-CT EDA, MEN EXD CEF, CLI, oral ketoconazole STE
Vadiee et al. [105] 2023 12 F IB CT, ce-MRI EDA CRA ceftazidime, VAN, MET Polybacterial
van der Poel et al. [106] 2016 7 F T ce-CT, ce-MRI SDA, SSST ESS, CRE penicillin S. intermedius
10 F ARS ce-CT, ce-MRI None ESS AMOC Commensale flora
12 F ARS ce-CT, ce-MRI EDA ESS, CRE AMOC, then penicillin, MET S. constellatus
13 M ARS ce-CT, ce-MRI None None AMOC Streptococcus
17 M ARS ce-CT, ce-MRI EDA ESS, CRE penicillin, MET S. intermedius
Vanderveken et al. [107] 2012 5 M ARS ce-CT EDA EXD, CRA AMOC STE
Vaphiades et al. [108] 2023 10 M ARS ce-MRI EDA, SSST, MEN EXD, CRA BSATB NA
Verma et al. [109] 2021 14 M ARS ce-CT EDA EXD, ESS, CRA CEF Streptococcus
Verma et al. [110] 2018 15 M ARS ce-CT None ESS CEF, VAN, MET NA
12 M AFRS CT EDA ESS itraconazole NA
12 F ARS CT None ESS BSATB STE
Weinberg et al. [111] 2005 11 F ARS ce-CT None ESS cefotaxime, VAN, MET Group C Beta Streptococcus
Wu et al. [112] 2009 12 F AP ce-CT None EXD ceftazidime and gentamicin P. aeruginosa
Our case 2024 12 M ARS ce-CT, ce-MRI EDA ESS, CRA ceftazidime, VAN, MET S. intermedius

Abbreviations: AC = after culture; AFRS = allergic fungal rhinosinusitis; AMO = amoxicillin; AMOC = amoxicillin/clavulanate; AMP = ampicillin; AMPS = ampicillin/sulbactam; AP = acupuncture; ARS = acute pansinusitis; BA = brain abscess; BSATB = IV broad-spectrum antibiotics; ce-CT = contrast-enhanced computed tomography; ce-MRI = contrast-enhanced magnetic resonance imaging; CEF = ceftriaxon; CER = cerebritis; CLI = clindamycin; CRA = craniotomy; CRE = craniectomy; CRS = chronic rhinosinusitis; CST = cavernous sinus thrombosis; EDA = epidural abscess; ESS = Endoscopic Sinus Surgery; EXD = external drainage; F = female; FARS = frontal acute rhinosinusitis; FB = foreign body; FR = full recovery; I = influenza; IB = insect bite; LEV = levofloxacin; M = male; MAS = mastoiditis; MEN = meningitis; MER = meropenem; MET = metronidazole; NA = not available; OA = orbital abscess; OC = orbital cellulitis; PNC = pneumocephalus; PSC = preseptal cellulitis; RIF = rifampicin; S = streptococcus; SEP = septicemia; SD = scuba diving; SDA = subdural abscess; SSST = superior sagittal sinus thrombosis; Staph = staphylococcus; STE = sterile; T = trauma; TAZO = piperacillin/tazobactam; VAN = vancomycin; VOR = voriconazole.