Table 4.
Comparison of the clinical characteristics of gastric cancer after the eradication of primary lesions and serum gastrin and pepsinogen levels between the PPI and non-PPI groups.
| Variables | PPI (+), 31 Patients 35 Lesions | PPI (−), 63 Patients 74 Lesions | p Value |
|---|---|---|---|
| Gastrin (pg/mL) | <0.01 * | ||
| <99 | 3 (9) | 45 (72) | |
| ≥99 | 28 (91) | 18 (28) | |
| PG I/II ratio | 0.359 | ||
| <4.6 | 14 (45) | 22 (36) | |
| ≥4.6 | 17 (55) | 41 (64) | |
| Age (years) | <0.01 * | ||
| <70 | 8 (26) | 45 (71) | |
| ≥70 | 23 (74) | 18 (29) | |
| Smoking | 20 (65) | 42 (67) | 0.836 |
| Gastric cancer family history | 8 (25) | 16 (25) | 0.53 |
| Eradication period (years) | 0.965 | ||
| <10 | 23 (74) | 47 (75) | |
| ≥10 | 8 (26) | 16 (25) | |
| Gastric mucosal atrophy | 0.707 | ||
| Mild/moderate | 13 (42) | 29 (46) | |
| Severe | 18 (58) | 34 (54) | |
| Tumor size (mm) | 0.036 * | ||
| ≤10 | 16 (46) | 19 (26) | |
| >10 | 19 (54) | 55 (74) | |
| Tumor location | 0.097 | ||
| Upper/middle | 24 (69) | 51 (85) | |
| Lower | 11 (31) | 23 (15) | |
| Macroscopic type | 0.09 | ||
| Superficial elevated | 10 (29) | 11 (15) | |
| Superficial depressed | 25 (71) | 63 (85) | |
| Invasion depth | 0.641 | ||
| Mucosa | 33 (94) | 67 (93) | |
| Submucosa | 2 (6) | 7 (7) | |
| Synchronous tumor | 0.701 | ||
| Negative | 27 (87) | 53 (84) | |
| Positive | 4 (13) | 10 (16) | |
| Metachronous | 0.183 | ||
| (+) | 3 (10) | 13 (21) | |
| (−) | 28 (90) | 50 (79) |
(%) PPI, Proton pump inhibitor. *: a significant difference.