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. 2024 Oct 29;25(21):11617. doi: 10.3390/ijms252111617

Figure 2.

Figure 2

Figure 2

Figure 2

Histological analysis of spleen. (a) Severe amyloid deposition was detected in KCASP1Tg mice and not in 6-month-old WT mice. The marginal zone is the boundary between the white and red pulp, and dense deposition was detected (bar 200 μm). (b) The spleen was markedly enlarged in KCASP1Tg mice compared to WT controls. The weight was also high in IL-17F-/KCASP1Tg mice. (c) Amyloid deposition was rescued in IL-17A-/KCASP1Tg. Immunostaining for CD4, CD8, CD20, and CD138 was performed, and CD4-, CD8-, and CD20-positive cells were decreased in KCASP1Tg and IL-17F-/KCASP1Tg mice. On the contrary, CD138-positive cells were more stained in KCASP1Tg mice (×100 magnification). (d) The positive DFS staining area quantified by a Kruskal–Wallis test showed a significant increase in DFS positive area in KCASP1Tg mice, which decreased in IL-17A-/KCASP1Tg and IL-17AF-/KCASP1Tg mice. * p < 0.05, ** p < 0.01 and *** p < 0.001.