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Histological analysis of spleen. (a) Amyloidosis in the kidney was severe, and amyloid replaced glomeruli in KCASP1Tg mice (bar 200 μm). (b) In KCASP1Tg mice, the kidneys were markedly enlarged compared to WT mice. (c,d) Amyloid deposition was ameliorated in IL-17A-/KCASP1Tg and IL-17AF-/KCASP1Tg mice. (e) Urine protein and blood were detected in KCASP1Tg mice, which were also rescued in IL-17A-/KCASP1Tg mice. * p < 0.05, *** p < 0.001.
