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. 2024 Oct 29;25(21):11617. doi: 10.3390/ijms252111617

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The abdominal arteriosclerosis was ameliorated by the deletion of IL-17A and IL-17F (a) The arterial stricture was undetected in the thoracic aorta in all observed mice. The narrowing of the artery was observed in KCASP1Tg mice at the abdominal aorta. There were no pathological abnormalities at the abdominal aorta in KCASP1Tg mice. (b) The artery’s lumen circumference measurement showed a predominant decrease in the abdominal aorta of KCASP1Tg compared to WT mice. To investigate the effect of IL-17A, F, and AF in arteriosclerosis, the circumference of the lumen of the artery was measured in IL-17A-/KCASP1Tg, IL-17F-/KCASP1Tg, and IL-17AF-/KCASP1Tg mice. The circumference of the lumen of the artery was recovered at the abdominal portion in KCASP1Tg mice when crossing with IL-17A-, IL-17F-, and IL-17AF- mice. (c) The increase and specific amelioration in mRNA expression level for the enhanced gene, Apol11b, Camp, Chil3, S100a8, and S100a9, were undetected in mice groups measured at six months of old (Upper panel; thoracic aorta and Lower panel; abdominal aorta). * p < 0.05.

The abdominal arteriosclerosis was ameliorated by the deletion of IL-17A and IL-17F (a) The arterial stricture was undetected in the thoracic aorta in all observed mice. The narrowing of the artery was observed in KCASP1Tg mice at the abdominal aorta. There were no pathological abnormalities at the abdominal aorta in KCASP1Tg mice. (b) The artery’s lumen circumference measurement showed a predominant decrease in the abdominal aorta of KCASP1Tg compared to WT mice. To investigate the effect of IL-17A, F, and AF in arteriosclerosis, the circumference of the lumen of the artery was measured in IL-17A-/KCASP1Tg, IL-17F-/KCASP1Tg, and IL-17AF-/KCASP1Tg mice. The circumference of the lumen of the artery was recovered at the abdominal portion in KCASP1Tg mice when crossing with IL-17A-, IL-17F-, and IL-17AF- mice. (c) The increase and specific amelioration in mRNA expression level for the enhanced gene, Apol11b, Camp, Chil3, S100a8, and S100a9, were undetected in mice groups measured at six months of old (Upper panel; thoracic aorta and Lower panel; abdominal aorta). * p < 0.05.