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PhAs-LHP induced cell death and cell cycle arrest more potently than ATO. MiaPaCa-2 cells were treated with ATO (0.5 μM) or PhAs-LHP (0.05 μM) for 48 h (A). PANC-1 cells were treated with ATO (2 μM) or PhAs-LHP (0.2 μM) for 24 h (B). Both MiaPaCa-2 and PANC-1 cells were then stained with propidium iodide (PI) and subjected to flow cytometry analysis. Numbers indicate the percent of PI-negative cells of a total of 10,000 cells analyzed per condition (A).
