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. 2024 Oct 22;25(21):11366. doi: 10.3390/ijms252111366

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Arsenic distribution of PAO and PhAs-LHP. The brain, heart, liver, and kidney tissues from the mice of the control, Gem, PAO + Gem, and PhAs-LHP + Gem groups were analyzed by graphite furnace atomic absorption spectrophotometry (GFAAS) to determine the arsenic (As) concentrations (c). Heat maps showed the As distributions in these organs: (a) PAO + Gem; (b) PhAs-LHP + Gem. Colors represent the relative mean concentrations of As detected. Rel. Min. As, relative minimum amount of As detected, Rel. Max. As, relative maximum amount of As detected. Heat map figures (c) created in BioRender.com. (29 September 2024) The treatment groups are represented by: control group (black, n = 4), gemcitabine treatment (green, n = 4), PAO + gemcitabine (red, n = 5), and PhAs(LHP) + gemcitabine (blue, n = 5). Each data point represents the specified data from one mouse. Statistical significance with respect to the control group is indicated by: ns (not significant), †††† (p < 0.0001). Data are represented as the mean with the interquartile range.