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The expression of Skp2 was reduced by PAO, PhAs-LHP, and gemcitabine. Tumor tissues from the experiments shown in Figure 5 and Figure 6 were immunohistochemically stained by Skp2. The expression of Skp2 was decreased in the tumors of mice treated with PAO, PhAs-LHP, and gemcitabine. The combination of gemcitabine with PAO or PhAs-LHP did not further decrease the levels of Skp2. *, p < 0.05 compared to the untreated control. CT, control; Gem, gemcitabine.
