Table 2.
Pre-treatment pulmonary function tests by severity of ICI-p.
| Variable | Mild ICI-pa | Severe ICI-pa | P-value | |
|---|---|---|---|---|
| Spirometryb | 20 | 18 | ||
| FEV1 (mean, SD) | 2.17 (0.54) | 2.11 (0.79) | .77 | |
| FEV1pp (mean, SD) | 78.1 (20.4) | 67.1 (22.7) | .11 | |
| FVC (mean, SD) | 3.19 (0.82) | 2.90 (0.95) | 0.29 | |
| FVCpp (mean, SD) | 85.05 (15.54) | 66.24 (24.75) | .005 | |
| FEV1pp | <80% | 10 (50.0) | 12 (66.7) | .30 |
| >/=80% | 10 (50.0) | 6 (33.3) | ||
| FVCpp | <80% | 7 (35.0) | 12 (66.7) | .049 |
| >/=80% | 13 (65.0) | 6 (33.3) | ||
| Lung volumesb | 17 | 13 | ||
| TLC (mean, SD) | 6.15 (1.46) | 5.37 (1.34) | .13 | |
| TLCpp (mean, SD) | 99.71 (17.62) | 83.25 (10.82) | .004 | |
| TLCpp | <80% | 3 (17.6) | 4 (30.8) | .40 |
| >/=80% | 14 (82.4) | 9 (69.2) | ||
| Diffusion capacityc | 18 | 16 | ||
| DLCO (mean, SD) | 17.02 (5.03) | 17.45 (6.09) | .82 | |
| DLCOpp (mean, SD) | 75.50 (20.04) | 73.33 (28.09) | .79 | |
| DLCO corrected for hemoglobin (mean, SD) | 17.28 (4.78) | 18.31 (6.08) | .59 | |
| DLCO corrected for hemoglobin, pp | 79.60 (21.28) | 76.95 (27.82) | .76 | |
| DLCO corrected for hemoglobin, pp | <80% | 8 (53.3) | 10 (62.5) | .61 |
| >/=80% | 7 (46.7) | 6 (37.5) | ||
| Oxygen requirement before ICI (%) | Yes | 6 (10.2) | 13 (18.1) | .31 |
| No | 53 (89.8) | 59 (81.9) |
aGrading of ICI-p by CTCAE criteria version 4; Minor ICI-p (grade 1-2), severe ICI-p (grade 3-5).
bRaw values for FEV1, FVC, and TLC reported in liters.
cRaw values for diffusion capacity reported in mmol/min/mmHg.
Abbreviations: ICI-p, immune checkpoint inhibitor pneumonitis; FEV1, forced expiratory volume in 1 second; FVC, forced viral capacity; TLC, total lung capacity; DLCO, diffusion capacity of the lungs for carbon monoxide; p, percent predicted