Table 3.
Pre-treatment chest imaging and severity of ICI-p.
| Mild ICI-pa | Severe ICI-pa | P-value | ||
|---|---|---|---|---|
| Pre-treatment interstitial abnormalities | Yes | 35 (62.5) | 50 (73.5) | .19 |
| No | 21 (37.5) | 18 (26.5) | ||
| Consolidation | Yes | 0 (0.0) | 7 (10.3) | .003 |
| No | 56 (100.0) | 61 (89.7) | ||
| Ground glass | Yes | 23 (41.1) | 27 (39.7) | .88 |
| No | 33 (58.9) | 41 (60.3) | ||
| Reticular | Yes | 17 (30.4) | 30 (44.1) | .11 |
| No | 39 (69.7) | 38 (56.0) | ||
| Centrilobular nodules or bronchiolitis | Yes | 7 (12.5) | 12 (17.6) | .43 |
| No | 49 (87.5) | 56 (82.4) | ||
| Bronchiectasis | Yes | 0 (0.0) | 6 (8.8) | .006 |
| No | 56 (100.0) | 62 (91.2) | ||
| Honeycombing | Yes | 1 (1.8) | 2 (2.9) | .67 |
| No | 55 (98.2) | 66 (97.1) | ||
| Total interstitial severity score | 2.00 (1.00, 4.00) | 3.00 (1.25, 9.00) | .006 | |
| Pulmonary metastasesb | Yes | 8 (38.1) | 23 (63.9) | .059 |
| No | 13 (61.9) | 13 (36.1) |
aGrading of ICI-p by CTCAE criteria version 4; Minor ICI-p (grade 1-2), severe ICI-p (grade 3-5).
bOnly includes patients with metastatic pulmonary disease. Primary lung malignancies were not included.
Abbreviations: ICI-p, immune checkpoint inhibitor pneumonitis.