Table 2.
Cox regression analysis of metabolites associated with the risk of mortality.
| HMDB | Metabolite | Cases | Total | HR (95% CI) | p | Novel |
|---|---|---|---|---|---|---|
| Amino Acids | ||||||
| HMDB0341329 | Hydroxyasparagine | 1345 | 10,169 | 1.23 (1.16–1.29) | 2.1 × 10−15 | Yes |
| HMDB0000177 | Histidine | 1345 | 10,188 | 0.85 (0.81–0.88) | 3.2 × 10−15 | No |
| HMDB0000670 | Homoarginine | 1345 | 10,188 | 0.87 (0.82–0.91) | 1.8 × 10−8 | No |
| HMDB0002820 | 1-methyl-4-imidazoleacetate | 1333 | 10,125 | 1.25 (1.19–1.29) | <1.0 × 10−20 | Yes |
| HMDB0000600 | 5-(galactosylhydroxy)-L-lysine | 1165 | 8180 | 1.17 (1.10–1.24) | 3.8 × 10−7 | Yes |
| HMDB0000512 | N-acetylphenylalanine | 1317 | 9959 | 1.26 (1.19–1.32) | 3.0 × 10−17 | No |
| HMDB0240296 | C-glycosyltryptophan | 1345 | 10,188 | 1.26 (1.20–1.33) | <1.0 × 10−20 | Yes |
| HMDB0000679 | Homocitrulline | 1304 | 9837 | 1.19 (1.13–1.26) | 5.5 × 10−11 | No |
| HMDB0000323 | 3-amino-2-piperidone | 1344 | 10,180 | 1.15 (1.10–1.21) | 4.4 × 10−9 | Yes |
| HMDB0002201 | Carboxyehtyl-GABA | 1308 | 9898 | 1.14 (1.08–1.21) | 4.2 × 10−6 | Yes |
| Peptide | ||||||
| HMDB0012881 | N-acetylcarnosine | 1340 | 10,162 | 0.87 (0.83–0.92) | 2.3 × 10−7 | No |
| Nucleotides | ||||||
| HMDB0000026 | 3-ureidopropionate | 1236 | 9104 | 1.27 (1.12–1.33) | <1.0 × 10−20 | No |
| Fatty acids | ||||||
| HMDB0000345 | 3-hydroxyadipate | 1054 | 7933 | 1.25 (1.18–1.18) | 1.1 × 10−13 | Yes |
| HMDB0061661 | 9-hydroxystearate | 1191 | 9011 | 1.37 (1.30–1.44) | <1.0 × 10−20 | Yes |
| - | 2-hydroxynervonate | 1317 | 9773 | 1.37 (1.28–1.46) | <1.0 × 10−20 | Yes |
| HMDB0000409 | 5-hydroxyhexanoate | 1125 | 7220 | 1.23 (1.16–1.31) | 3.4 × 10−12 | No |
| HMDB0000511 | Caprate (10:0) | 1345 | 10,188 | 1.22 (1.16–1.28) | 1.3 × 10−14 | No |
| Sphingolipids | ||||||
| HMDB0000269 | Sphinganine | 1257 | 8796 | 1.22 (1.15–1.29) | 1.7 × 10−11 | Yes |
| HMDB0011697 | Lignoceroyl sphingomyelin | 1136 | 7896 | 0.88 (0.31–0.93) | 9.9 × 10−6 | Yes |
| HMDB0240671 | Sphingomyelin (d18:1/25:0) | 1136 | 7893 | 0.85 (0.80–0.90) | 6.8 × 10−9 | Yes |
| HMDB0012091 | Behenoyl dihydrosphingomyelin | 1337 | 10,008 | 0.89 (0.51–0.94) | 1.1 × 10−5 | Yes |
| Acylcarnitines | ||||||
| - | Suberoylcarnitine (C8-DC) | 1163 | 8684 | 1.31 (1.24–1.39) | <1.0 × 10−20 | No |
| HMDB0013127 | (R)-3-hydroxybutyrylcarnitine | 1292 | 9620 | 1.22 (1.15–1.38) | 8.9 × 10−13 | Yes |
| - | (S)-3-hydroxybutyrylcarnitine | 1334 | 10,014 | 1.20 (1.14–1.26) | 1.0 × 10−11 | Yes |
| Steroids | ||||||
| - | Pregnenetriol sulfate | 1345 | 10,187 | 0.89 (0.85–0.94) | 9.8 × 10−6 | Yes |
| Carbohydrates | ||||||
| HMDB0000212 HMDB0000215 |
N-acetylglucosamine/N N-acetylgalactosamine | 1334 | 10,053 | 1.30 (1.23–1.38) | <1.0 × 10−20 | No |
| HMDB0000169 | Mannose | 1345 | 10,185 | 1.22 (1.16–1.29) | 9.9 × 10−13 | Yes |
| Energy | ||||||
| HMDB0031518 | Malate | 1345 | 10,188 | 1.33 (1.26–1.39) | <1.0 × 10−20 | No |
| Endocannab. | ||||||
| HMDB0002088 | Oleoylethanolamide | 1109 | 7189 | 1.18 (1.11–1.26) | 7.2 × 10−8 | Yes |
| Organic compound | ||||||
| HMDB0304531 | Vanillylmandelate | 1202 | 8816 | 1.12 (1.06–1.19) | 1.2 × 10−4 | No |
| Xenobiotics | ||||||
| - | 5-hydroxymethyl-2-furoylcarnitine | 953 | 7071 | 1.22 (1.14–1.30) | 1.6 × 10−9 | Yes |
| - | 2-hydroxyfluorene sulfate | 932 | 6556 | 1.30 (1.22–1.38) | 8.5 × 10−16 | Yes |