Table 5.
Overrepresented KEGG metabolic pathways for the combined set of primary and secondary metabolomic markers. Metabolites that are primary and secondary markers are marked in bold.
| KEGG Pathway | Total | FDR | Primary Metabolomic Markers (Hits) | Secondary Metabolomic Markers (Hits) |
|---|---|---|---|---|
| Glycine, serine, and threonine metabolism | 33 | 0.0021 | Betaine; Glyceric acid | L-Serine; Choline; Betaine aldehyde; Guanidoacetic acid; Cystathionine; L-Threonine; Glyceric acid |
| Aminoacyl-tRNA biosynthesis | 48 | 0.0028 | L-Leucine; L-Tryptophan; L-Tyrosine | L-Histidine; L-Arginine; L-Serine; L-Valine; L-Threonine; L-Proline |
| Tryptophan metabolism | 41 | 0.0239 | L-Tryptophan; 5-Hydroxy-L-tryptophan | Serotonin; 3-Hydroxyanthranilic acid; L-Kynurenine; Acetyl-CoA |
| Arginine biosynthesis | 14 | 0.0351 | N-Acetylglutamic acid | L-Arginine; Citrulline; Ornithine |
| Butanoate metabolism | 15 | 0.0372 | 3-hydroxybutyric acid; Gamma-Aminobutyric acid; D-2-Hydroxyglutaric acid | 3-hydroxybutyric acid; Acetyl-CoA; Gamma-Aminobutyric acid |
| Valine, leucine, and isoleucine biosynthesis | 8 | 0.0375 | L-Leucine | L-Threonine; L-Valine |
| Arginine and proline metabolism | 38 | 0.0375 | Gamma-Aminobutyric acid | L-Arginine; Guanidoacetic acid; Gamma-Aminobutyric acid; Spermine; Ornithine; L-Proline |
| Pyrimidine metabolism | 39 | 0.0376 | Cytidine; Thymine; Ureidosuccinic acid; Uracil | Uridine; Ureidosuccinic acid; Uracil; Deoxyribose 1-phosphate |
| Ubiquinone and other terpenoid-quinone biosynthesis | 9 | 0.0394 | L-Tyrosine; Homogentisic acid | Phenyllactic acid |