. 2024 Nov 4;25(21):11847. doi: 10.3390/ijms252111847

Table 7.

Descriptive features of gene network of regulation of lactate metabolic pathway enzymes.

№	KEGG Lactate Metabolism Pathways	Enzymes in the Metabolic Pathway	Regulatory Genetic Markers
1	Glycolysis/Gluconeogenesis: hsa00010;	LDHA	APOE, CCL2, GDNF, HMGB1, IGF1, IFNG, IL1B, IL2, IL6, IL6RA, IL8, IL10, LEP, TLR4, TNFA
1	Glycolysis/Gluconeogenesis: hsa00010;	LDHB	IL1B, S100B, TNFA
2	HIF-1 signaling pathway: hsa04066	LDHB	IL1B, S100B, TNFA
2	HIF-1 signaling pathway: hsa04066	LDHC, LDHAL6A, LDHAL6B	-
3	Pyruvate metabolism: hsa00620	GLO2	APOE
		LDHA	APOE, CCL2, GDNF, HMGB1, IGF1, IFNG, IL1B, IL2, IL6, IL6RA, IL8, IL10, LEP, TLR4, TNFA
		LDHB	IL1B, S100B, TNFA
		GLUL, GRHPR, HAGH, LDHC, LDHD, LDHAL6A, LDHAL6B	-