Table 8.
Characteristics of gene regulatory network of inositol metabolic pathway enzymes.
| № | KEGG inositol Metabolism Pathways | Enzymes in the Metabolic Pathway | Regulatory Genetic Markers |
|---|---|---|---|
| 1 | Inositol phosphate metabolism: hsa00562 |
IMPA1 | S100B |
| IMPA2 | THIO | ||
| INP4B | CCL2, IGF1, IL6, IL6RA, IL8, LEP | ||
| INP5K | BDNF | ||
| ITPR3 | HMGB1, IL6, IL8, LEP, MMP9, TLR4 | ||
| CDIPT, INP1, INP4A, ISYNA1, MIOX, MTM1 | - | ||
| 2 | Phosphatidylinositol signaling system: hsa04070 |
IMPA1 | S100B |
| IMPA2 | THIO | ||
| INP4B | CCL2, IGF1, IL6, IL6RA, IL8, LEP | ||
| PLCB2, PLCD1 | IL6, IL8, LEP | ||
| PLCG1 | PECA1 | ||
| PLCG2 | TAU | ||
| BPNT2, CDIPT, INP1, INP4A, INP5A, MTM1, PLCs | - | ||
| 3 | Ascorbate and aldarate metabolism: hsa00053 | MIOX | - |