Table 9.
Characteristics of gene regulatory network of GABA metabolic pathway enzymes.
| № | KEGG GABA Metabolism Pathways | Enzymes in the Metabolic Pathway | Regulatory Genetic Markers |
|---|---|---|---|
| 1 | GABAergic synapse: hsa04727 |
GLSK | GDNF, GCR, HMGB1, IGF1, IFNG, IL1B, IL1RA, IL2, IL6, IL8, IL10, LEG3, LEP, TLR4 |
| GLSL | GCR, IGF1, IL1RA, IL6, IL8, IL10, LEG3, LEP, TLR4 | ||
| GAD1 | APOE, BDNF, GCR, GDNF, IL1B, IL2, IL6 | ||
| GAD2 | GCR, IL2 | ||
| GABT | - | ||
| 2 | Arginine and proline metabolism: hsa00330 | ALDH2 | IL2 |
| ALDH1B1, ALDH3A2, ALDH7A1, ALDH9A1, CNDP1, CNDP2, GATM | - | ||
| 3 | Butanoate metabolism: hsa00650 | GAD1 | APOE, BDNF, GCR, GDNF, IL1B, IL2, IL6 |
| GAD2 | GCR, IL2 | ||
| GABT | - |