Table 10.
Characteristics of gene regulatory network of the enzymes in serotonin metabolic pathways.
| № | KEGG Serotonin Metabolism Pathways | Enzymes in the Metabolic Pathway | Regulatory Genetic Markers |
|---|---|---|---|
| 1 | Serotonergic synapse: hsa04726 | TPH1 | ALBU, GCR, IGF1, IL1B, IL2, IL6, IL10, LEP, THIO, TLR4, TNFA |
| DDC | BDNF, GDNF, IGF1, IL2, LEP | ||
| TPH2 | GCR, LEP | ||
| AOFA | APOE, TLR4 | ||
| AOFB | APOE, LEP | ||
| 2 | Tryptophan metabolism: hsa00380 | I23O1 | ALBU, CCL2, GCR, HMGB1, IFNG, IL1B, IL2, IL6, IL8, IL10, LEG3, LEP, TLR4, TNFA, TNR1B |
| DDC | BDNF, GDNF, IGF1, IL2, LEP | ||
| I23O2 | IL2, LEP | ||
| AOFA | APOE, TLR4 | ||
| AOFB | APOE, LEP | ||
| INMT, SNAT | - |