Skip to main content
. 2024 Sep 12;18(6):101402. doi: 10.1016/j.jcmgh.2024.101402

Figure 1.

Figure 1

XBP1 expression in macrophages is increased and positively correlates with IR-induced liver injury in patients. Liver tissues and macrophages were harvested from 25 patients undergoing PH. (A-D) Prehepatectomy/posthepatectomy XBP1s expression profiles in liver tissues and macrophages (representative 6 cases) through Western blotting assay. (B, C) Expressions of XBP1 mRNA in liver tissues and in liver macrophages. (E) Dual-immunofluorescence staining for XBP1 (green) and CD68 (red) colocalization in human liver tissues, which were also subjected to HE and TUNEL analysis. (F) Twenty-five patients were divided into the low (n = 12) and high (n = 13) groups using the postoperative median XBP1/GAPDH ratio as the threshold. (G) The ratio of posthepatectomy XBP1/GAPDH positively correlated with serum ALT and AST levels at POD1. (H) Serum ALT and AST levels were measured at POD1 in both low and high groups. ∗P < .05 by Student t test.