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Xenogenic nucleic acids (XNAs).
| Modification | Target | Result KD | Reference |
|---|---|---|---|
| Threose nucleic acid (TNA) | S1 protein in SARS-CoV-2 | KD values of 3.1 ± 1.0 | [135] |
| Threose nucleic acid (TNA) | HIV reverse transcriptase (HIV RT) | KD = 0.4–4.0 nM | [136] |
| 2′-O-methyl-ribose-1,5 anhydrohexitol nucleic acid (MeORNA-HNA) | VEGF164 target protein | KD = 1.1 nM | [137] |
| P-alkyl phosphonate nucleic acids (phNA) | streptavidin (SA) | affinities in the low millimolar range. | [138] |
