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. 2024 Oct 23;25(21):11393. doi: 10.3390/ijms252111393

Figure 2.

Figure 2

Effect of IL-1Ra on neurobehavioral impairments in offspring exposed in utero to GBS chorioamnionitis. (a) The latency before social interaction and (b) the number of social episodes were assessed during a 5 min period in an open-field apparatus at P40. (c) The travelled distance and (d) number of lines crossed were measured during a 5 min period in the open field at P80. Pairs of animals (from 4 to 6 litters) per experimental group were used for the social interaction test. n = 4–9 animals per experimental group from 4–5 litters were used for the open-field test. n = 3–6 animals per experimental group from 4–5 litters were used for IL-1ß titers. Data were expressed as mean ± SEM. * p < 0.05, ** p < 0.01, using one-way ANOVA. (e) A significant correlation was found between IL-1ß blood titers at P1 and the distance travelled at P80 in males but not females, using the Spearman correlation test, p < 0.05.