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Rejuvenation of tendon stem/progenitor cells (TSPCs) for tendon regeneration. (A) Causes of rotator cuff disease. Chronic inflammation and tendon tissue defects due to exhaustion of TSPCs. (B) Strategies for TSPC reprogramming. Tendon regeneration through the rejuvenation of TSPCs using a combination of extracellular vesicles derived from fetal mesenchymal stem cells (MSCs) and small molecules.
