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Rosa canina methanol extract (RCME) treatment inhibited the cholesterol accumulation in NPC1 patients. The fibroblasts derived from a healthy donor (WT), patient 1 (P1), patient 2 (P2), patient 3 (P3), and patient 4 (P4), were treated for 24 h with RCME, miglustat (Mig) or RCME + Mig. After cholesterol extraction, the measurement was performed with HPLC. Ordinary one-way ANOVA, ns p > 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0005 versus untreated group, S.E.M., and n = 3.
