Table 5.

Comparison of the characteristics and effects of MRAs.

	Steroidal MRA		Non-Steroidal MRA
Characteristics	Spironolactone	Eplerenone	Finerenone
Antagonism over MR	High	Low	High
Antagonism over AR	High	Low	Low
Effect on proteinuria and kidney damage	Moderate	Low	High
BP reduction	High	Low	High
Effect on HFpEF	Moderate	Moderate	High
Effect on HFmrEF	Moderate	Moderate	High
Effect on HFrEF	High	High	High
Hyperkalemia	High	Moderate	Low
Gynecomastia	High	Moderate	Low

MRA = mineralocorticoid receptor antagonist; MR = mineralocorticoid receptor; AR = androgen receptor; BP = blood pressure; HFpEF = heart failure with preserved ejection fraction; HFmrEF = heart failure with moderately reduced ejection fraction; HFrEF = heart failure with reduced ejection fraction.