Table 2.
Absolute changes in the biochemical parameters at 72 h following cholecalciferol or placebo supplementation. Time 0 vs. time 72 h in each group * p < 0.05.
| 25,000 I.U. | 600,000 I.U. | Controls | ||||
|---|---|---|---|---|---|---|
| 0 | 72 | 0 | 72 | 0 | 72 | |
| Ca++ (mmol/L) | 1.24 ± 0.04 | 1.27 ± 0.04 | 1.24 ± 0.03 | 1.28 ± 0.16 * | 1.21 ± 0.08 | 1.22 ± 0.72 |
| 25(OH)D (ng/mL) | 12.2 ± 8.8 | 19.9 ± 11.3 * | 16.55 ± 13.1 | 58.6 ± 29.4 * | 11.5 ± 8.6 | 15.5 ± 11.9 |
| 1,25(OH)2D (pg/mL) | 27.8 ± 11.3 | 38.6 ± 15.8 * | 39.8 ± 13.55 | 70.5 ± 17.1 * | 34.8 ± 12.6 | 30.3 ± 10.25 |
| 24,25(OH)2D (ng/mL) | 0.72 ± 0.76 | 0.95 ± 0.98 | 0.72 ± 0.75 | 2.56 ± 1.52 | 0.50 ± 0.45 | 0.59 ± 0.32 |
| PTH (pg/mL) | 74.0 ± 57.7 | 71.7 ± 61.1 | 46.0 ± 13.1 | 38.7 ± 16.6 | 55.2 ± 36.0 | 59.7 ± 61.3 |
| FGF23 (ng/mL) | 39.7 ± 26.9 | 38.9 ± 18.08 | 48.2 ± 18.7 | 68.9 ± 34.2 * | 40.0 ± 13.85 | 37.5 ± 27.3 |
| 1,25(OH)2D/25(OH)D | 0.002 ± 0.001 | 0.002 ± 0.001 | 0.003 ± 0.001 | 0.001 ± 0.001 * | 0.004 ± 0.001 | 0.004 ± 0.004 |
| 1,25(OH)2D/24,25(OH)2D | 0.16 ± 0.20 | 0.07 ± 0.08 | 0.13 ± 0.10 | 0.06 ± 0.06 * | 0.14 ± 0.12 | 0.06 ± 0.03 |
| 24,25(OH)2D/25(OH)D | 0.11 ± 0.12 | 0.07 ± 0.04 | 0.04 ± 0.03 | 0.03 ± 0.01 | 0.06 ± 0.08 | 0.07 ± 0.06 |