Table 1.

PICOS criteria for the inclusion of RCTs in which the supplementation of creatine was combined with a well-structured resistance training program and pre–post-training strength gain was compared with placebo supplementation with resistance training.

Parameters	Inclusion	Exclusion
Population	Healthy individuals under the age of 50	Individuals with diseases or those over the age of 50.
Intervention	Creatine supplementation with structured resistance training	Creatine supplementation with other types of training (e.g., aerobic training), with unstructured training or without any type of training
Comparison	Placebo with the same structured resistance training as the intervention group	Placebo without resistance training or resistance training without a placebo
Outcomes	Muscle strength gains	Any other form of performance or anthropometric assessments
Study design	Randomized controlled trials (RCTs)	Meta-analyses, articles without full text, acute interventions, non-peer-reviewed articles, opinion pieces, reviews, case reports, and editorials