Figure 3.

(a) Modifications to the 3′ and 5′ ends of Dz-00 and the activity variation for the mutated species (Dz-11 to Dz-18). (b) Decrease in activity due to increase in spacer length. (c) A mechanism for DNAzyme-catalyzed cleavage of oligonucleotide monomers. (d) Single point mutations to the four main catalytic bases of NaH1 (left) and their respective rates. (e) A comparison of NaA43T to NaH1 at different pH values, including other mutations showing less significant results. Adapted from Refs. [113,124] with permission.