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Chromatographic separation of metformin and D6-metformin in solution using the TFA and HFBA aqueous ammonia approaches in a Waters Xevo TQ-S with an Acquity BEH Peptide Column. Using TFA, the retention time was unsatisfactory, and a small shoulder peak can be seen. The change to HFBA caused an acceptable retention time as well as good peak shape and width.
