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. 2024 Oct 26;24(21):6875. doi: 10.3390/s24216875

Figure 3.

Figure 3

Mechanism of interaction of the EY615QF aptamer design with Spike. (A) Fluorescence of EY615QF aptamer (6.5 nM) with and without Spike protein (100 nM). (A,B) Left section: anticipated fluorescence events; right section: fluorescence measurements. (B) Fluorescence of EY615QF interaction with RCA/LAMP primers (EY616 and EY617 at 3µM each; sequence details in Table S1) in the presence/absence of Spike protein (100 nM). (C) Theoretical structure model of the EY615QF aptamer and Spike protein interaction and its hypothetical impacts on RCA and LAMP initiations. Representation of nucleotides and amino acids as in Song et al. [32].