Table 10.

Experimental design and data values.

Run	Factors								Responses
	Coded				Actual
	A	B	C	D	Temperature, °C	Time, min	Amplitude, %	Solvent	TPC, mg GAE/g	DPPH, %
1	−1	−1	0	{ 1 0 }	30	10	70	water	53.41	71.50
2	1	−1	0	{ 1 0 }	50	10	70	water	111.84	77.61
3	−1	1	0	{ 1 0 }	30	20	70	water	126.88	83.00
4	1	1	0	{ 1 0 }	50	20	70	water	102.05	78.47
5	−1	0	−1	{ 1 0 }	30	15	40	water	30.00	65.55
6	1	0	−1	{ 1 0 }	50	15	40	water	46.00	80.19
7	−1	0	1	{ 1 0 }	30	15	100	water	142.32	81.70
8	1	0	1	{ 1 0 }	50	15	100	water	117.00	56.93
9	0	−1	−1	{ 1 0 }	40	10	40	water	19.00	78.47
10	0	1	−1	{ 1 0 }	40	20	40	water	104.48	75.02
11	0	−1	1	{ 1 0 }	40	10	100	water	174.00	75.00
12	0	1	1	{ 1 0 }	40	20	100	water	151.4	74.16
13	0	0	0	{ 1 0 }	40	15	70	water	47.00	83.63
14	0	0	0	{ 1 0 }	40	15	70	water	46.92	76.31
15	0	0	0	{ 1 0 }	40	15	70	water	46.92	76.14
16	−1	−1	0	{ 0 1 }	30	10	70	ethanol	47.31	44.53
17	1	−1	0	{ 0 1 }	50	10	70	ethanol	75.15	66.33
18	−1	1	0	{ 0 1 }	30	20	70	ethanol	63.35	72.22
19	1	1	0	{ 0 1 }	50	20	70	ethanol	25.00	58.00
20	−1	0	−1	{ 0 1 }	30	15	40	ethanol	7.14	40.24
21	1	0	−1	{ 0 1 }	50	15	40	ethanol	45.84	65.49
22	−1	0	1	{ 0 1 }	30	15	100	ethanol	51.54	67.00
23	1	0	1	{ 0 1 }	50	15	100	ethanol	9.41	41.08
24	0	−1	−1	{ 0 1 }	40	10	40	ethanol	35.00	50.00
25	0	1	−1	{ 0 1 }	40	20	40	ethanol	35.02	63.80
26	0	−1	1	{ 0 1 }	40	10	100	ethanol	84.29	54.00
27	0	1	1	{ 0 1 }	40	20	100	ethanol	47.77	70.00
28	0	0	0	{ 0 1 }	40	15	70	ethanol	8.00	80.00
29	0	0	0	{ 0 1 }	40	15	70	ethanol	8.00	70.00
30	0	0	0	{ 0 1 }	40	15	70	ethanol	8.00	70.00
31	−1	−1	0	{ −1 −1 }	30	10	70	methanol	112.43	82.34
32	1	−1	0	{ −1 −1 }	50	10	70	methanol	83.00	81.00
33	−1	1	0	{ −1 −1 }	30	20	70	methanol	175.72	74.00
34	1	1	0	{ −1 −1 }	50	20	70	methanol	81.06	73.09
35	−1	0	−1	{ −1 −1 }	30	15	40	methanol	83.00	70.56
36	1	0	−1	{ −1 −1 }	50	15	40	methanol	128.39	87.40
37	−1	0	1	{ −1 −1 }	30	15	100	methanol	141.21	78.55
38	1	0	1	{ −1 −1 }	50	15	100	methanol	28.14	49.54
39	0	−1	−1	{ −1 −1 }	40	10	40	methanol	118.3	89.07
40	0	1	−1	{ −1 −1 }	40	20	40	methanol	193.63	82.34
41	0	−1	1	{ −1 −1 }	40	10	100	methanol	135.89	81.50
42	0	1	1	{ −1 −1 }	40	20	100	methanol	114.21	70.00
43	0	0	0	{ −1 −1 }	40	15	70	methanol	67.00	86.00
44	0	0	0	{ −1 −1 }	40	15	70	methanol	68.00	85.70
45	0	0	0	{ −1 −1 }	40	15	70	methanol	66.79	86.00