Fig 5. Comparison of multi-organ gene regulatory networks in male and female SHR vs.

WKY. A,B: Network of organ-organ interactions in SHR (left) and WKY (right) (A: female, B: male). The edge thickness and color are mapped to the number of interactions within two standard deviations of the mean. C-D: Heat map of interaction coefficients within two standard deviations of the mean in SHR (top) and WKY (bottom) (C: female, D: male). E,F: Network of organ-organ interactions in SHR (top) and WKY (bottom) in female (panel E) and male (panel F). The edges shown correspond to the absolute interaction coefficients greater than 75% of maximum value (female SHR) and 25% of maximum value (female WKY, as well as male SHR and WKY). The edge thickness and color are mapped to the level of the interaction coefficients.