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. 2024 Nov 8;19(11):e0313025. doi: 10.1371/journal.pone.0313025

Table 1. Descriptions of studies on participants with peripheral neuropathic pain.

Study Design Country Study population Techniques Intervention and comparator Outcomes measured
Pinar 2005 [45] RCT Turkey CTS (n = 26) Tension Splint plus patient training program or splint plus patient training program plus neural mobilisation Before and 10-week after intervention
• NCS (electrophysiologic test): distal motor latency
Baysal et al. 2006 [7] RCT Turkey CTS (n = 36) Tension Splinting plus neural mobilisation or splinting plus ultrasound or splinting plus neural mobilisation plus ultrasound Before, after intervention, and 8-week after intervention
• NCS: motor latency, sensory latency
Bialosky et al. 2009 [47] RCT United States CTS (n = 40) Tension Neural mobilisation or sham technique Before and after intervention
• NCS (electrodiagnostic test): distal motor latency
Svernlöv et al. 2009 [48] RCT Sweden Cubital Tunnel Syndrome
n = 70
(n = 39 women and n = 31 men)
Tension Splinting plus information or neural mobilisation plus information or information Before and 6-month after intervention
• NCS: sensory conduction velocity, motor conduction velocity, electromyography
Schmid et al. 2012 [23] RCT Australia CTS (n = 20) Sliding Splinting or neural mobilisation home program Before, 10-minute after intervention, and 1-week after intervention
• Nerve structure evaluation: signal intensity
Oskouei et al. 2014 [54] RCT Iran CTS n = 20 (n = 16 hands in each group) Tension Routine physiotherapy (splint, TENS, and therapeutic ultrasound) or routine physiotherapy plus neural mobilisation Before and 4-week after intervention
• NCS: motor distal latency and sensory distal latency
Ginanneschi et al. 2015 [42] QES Italy CTS
n = 16
[n = 8 hands (men = 1; women = 7) and 8 healthy participants]
Tension Neural mobilisation Before and after intervention
• NCS: sensory conduction velocity, sensory action potential amplitude, distal motor latencies
Wolny et al. 2017 [49] RCT Poland CTS (n = 140) Sliding and tension Neural mobilisation plus functional massage plus bone mobilisations techniques or laser plus ultrasound therapy Before and after intervention
• NCS: sensory conduction velocity, motor conduction velocity, motor latency, standardized latency
Yildirim et al. 2018 [46] RCT Turkey CTS (n = 21) Tension Kinesiotaping plus neural mobilisation or neural mobilisation Before, 3-week after intervention, and 6-week after intervention
• Nerve structure evaluation: CSA
Wolny & Linek, 2018 [50] RCT Poland CTS (n = 150) Sliding and tension Neural mobilisation or “sham” therapy Before and after intervention
• NCS: sensory conduction velocity, motor conduction velocity, motor latency
Neto et al. 2019 [43] QES Portugal Sciatica n = 16 (n = 8 chronic sciatica and n = 8 health participants) Tension Neural mobilisation Before and after intervention
• Nerve structure evaluation: nerve stiffness (SWV)
Wolny & Linek, 2019 [51] RCT Poland CTS (n = 103) Sliding and tension Neural mobilisation or control group NCS: Before and 1-month after treatment
• NCS: sensory conduction velocity, motor conduction velocity, motor latency
Paquette et al. 2020 [44] QES Canada CTS (n = 14) Sliding Neural mobilisation home program plus videoconference plus logbook Before and 1-week after the completion of a 4-week intervention program
• NCS (US): nerve biological integrity, nerve mechanical properties
Talebi et al. 2020 [52] RCT Iran CTS (n = 30) Tension Nerve mobilisation or mechanical interface mobilisation Before and immediately after the end of the treatment period
• NCS: motor distal latency, sensory distal latency
Khademi et al. 2023 [53] QES Iran CTS (n = 20) Tension Neural mobilisation Before and immediately after one session of neural mobilisation
• Nerve structure evaluation: nerve stiffness
• Nerve structure evaluation: CSA

Abbreviations: CSA = Cross-Sectional Area; CTS = Carpal Tunnel Syndrome; NCS = Nerve Conduction Studies; QES = Quasi-Experimental Study

RCT = Randomised Clinical Trials; SWV: Shear Wave Velocity; TENS = Transcutaneous Electrical Nerve Stimulation.