Table 5.
Perinatal blockade of neuronal glutamine uptake by MeAIB (5 mm, icv) on PN5 had no effect on locomotor activity and anxiety-like behavior in both sexes during adulthood
Test | Locomotion, s | Rearing, n | Time spent in corner, s | Time spent in any squares other than corner, s | Freezing time, s | |||||
---|---|---|---|---|---|---|---|---|---|---|
Sex | male | female | male | female | male | female | male | female | male | female |
Pretreatment | ||||||||||
DW | 481.6±13.8 | 447.3±11.3 | 56.3±3.9 | 57.9±3.9 | 21.3±7.3 | 26.8±7.9 | 73.5±8.5 | 105.4±14.9 | 0±0 | 0±0 |
MeAIB | 451.8±26.6 | 481.2±18.7 | 59.0±4.9 | 66.8±4.9 | 24.0±11.8 | 28.8±5.6 | 99.2±29.6 | 75.2±17.3 | 0±0 | 0±0 |
There were 7 animals of each sex per group.
icv, intracerebroventricular injection; PN, postnatal day; DW, distilled water.