FIG 2.

Illustration of how the list of explorable DLs for the TALE design is updated throughout the trial. The figure includes two components (A and B) to summarize the available data up to stage k and two more components (C and D) translating available data into the decision of which DLs will be assigned during the next stage (k+1). The set L_k includes all the (i, j) dose combinations assigned during the k-th stage. For example, L₃ = {(1, 3), (2, 1)} indicates that during the third stage, two distinct dose combinations are explored (1, 3) and (2, 1). DLs, dose levels; TALE, Toxicity Adaptive Lists Design.