TABLE 2.
Comparison of the TALE With Existing Model-Based and Model-Assisted Methods in Terms of the Percentage of Overdose Assignment and Percentage of Underdose Assignment (metrics e and f)
| Scenario | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | Average |
|---|---|---|---|---|---|---|---|---|---|
| Percentage of overdose assignment | |||||||||
| TALE | 1.5 | 0.05 | 0 | 5.2 | 1.5 | 9.8 | 14.3 | 6.3 | 4.8 |
| BOIN | 4.8 | 2.8 | 4.7 | 12.7 | 11.8 | 22.1 | 24.4 | 9.5 | 11.6 |
| COPULA | 9.3 | 2.4 | 3.8 | 11.2 | 12.4 | 21.4 | 19 | 6.7 | 10.8 |
| POCRM | 5 | 0 | 1 | 11 | 6 | 13 | 5 | 7 | 6 |
| PIPE | 6.8 | 0.8 | 1.5 | 8.6 | 6.6 | 22.8 | 7.8 | 11.7 | 8.3 |
| Percentage of underdose assignment | |||||||||
| TALE | 15.2 | 12.0 | 54.8 | 70.1 | 65.6 | 60 | 34 | 42.7 | 44.3 |
| BOIN | 33.3 | 37.1 | 44.9 | 52.9 | 14.1 | 53.2 | 37.2 | 40 | 39.1 |
| COPULA | 1.9 | 0.24 | 30.0 | 45.9 | 36.2 | 47.6 | 25 | 28.3 | 26.9 |
| POCRM | 19 | 12 | 40 | 47 | 45 | 49 | 15 | 30 | 32.1 |
| PIPE | 15.7 | 11.4 | 37.7 | 53.9 | 46.2 | 46.5 | 16.5 | 31.7 | 32.4 |
Abbreviations: BOIN, Bayesian optimal interval design; PIPE, product of independent beta probabilities escalation; POCRM, continual reassessment method for partial ordering; TALE, Toxicity Adaptive Lists Design.