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. Author manuscript; available in PMC: 2024 Nov 8.
Published in final edited form as: Synapse. 2019 Jan 22;73(5):e22088. doi: 10.1002/syn.22088

Fig. 2. Female but not male CIS rats develop oxycodone CPP.

Fig. 2.

A. During the preconditioning phase, female and male CIS rats displayed a pre-test preference for the white side of the chamber. Thus, a biased CPP design was used in which rats were placed in the least-preferred side following the oxycodone injection. On the testing day, saline-injected (Sal) rats showed no preference for either chamber. However, the percent change in preference score for the oxycodone-injected (Oxy) chamber is higher in CIS female rats compared to their Sal counterparts. Oxy-CIS males did not show a significantly greater preference for the oxycodone chamber than their saline-injected counterparts. SF, Sal-female; SM, Sal-male; OF, Oxy-female; OM, Oxy-male. *p ≤ 0.05; N = 6 rats per group.