TABLE 2.

Cox‐regression uni‐variate analysis for ARAT‐failure survival.

	Univariate analysis						Multi‐variate analysis
	B	SE	Wald	df	p	Exp (B)	p	Exp (B)
General parameters
Age	0.013	0.006	4.454	1.000	0.035*	1.013	0.021*	1.020
BMI	−0.033	0.017	3.890	1.000	0.049*	0.968	0.152	0.974
ECOG	−1.056	0.589	3.223	1.000	0.002**	0.348	0.471
ISUP Group	0.154	0.055	7.787	1.000	0.005**	1.166	0.001**	1.223
DeNovo Mets	0.172	0.143	1.434	1.000	0.231	1.187
1st ARAT agent	0.278	0.117	5.619	1.000	0.018*	1.321	0.386	1.128
Chemotherapy Naïve	−0.586	0.131	20.137	1.000	< 0.0001**	0.556	< 0.0001**	0.407
Duration from HSPC to CRPC	0.000	0.000	1.300	1.000	0.254	1.000
Serum markers
iPSA	0.000	0.000	0.725	1.000	0.395	1.000
Nadir PSA during ADT	0.003	0.001	8.444	1.000	0.004**	1.003	0.421	1.001
PSA when starting ARAT	0.000	0.000	3.504	1.000	0.061	1.000

Abbreviations: ADT = androgen deprivation therapy; ARAT = androgen receptor‐axis‐targeted therapies; BMI = Body Mass Index; ECOG = Eastern Cooperative Oncology Group; ISUP = International Society of Urological Pathology; PSA = prostate‐specific antigen.

^* p < 0.05.

^** p < 0.01.