TABLE 3.

Cox‐regression uni‐variate analysis for overall survival.

	Univariate analysis						Multi‐variate analysis
	B	SE	Wald	df	p	Exp (B)	p	Exp (B)
General parameters
Age	0.025	0.008	9.722	1.000	0.002**	1.025	0.029*	1.020
BMI	−0.045	0.021	4.494	1.000	0.032*	0.956	0.079	0.963
ECOG			0.044	1.000	0.934	0.860
ISUP Group	0.162	0.066	5.928	1.000	0.013*	1.176	0.012*	1.183
DeNovo Mets	−0.085	0.165	0.266	1.000	0.606	0.919
1st ARAT agent	0.269	0.139	3.716	1.000	0.054	1.308
Pre‐ or post‐chemotherapy ARAT
Duration from HSPC to CRPC	0.000	0.000	2.671	1.000	0.102	1.000
Serum markers
iPSA	0.000	0.000	0.309	1.000	0.578	1.000
Nadir PSA during ADT	0.005	0.001	18.221	1.000	0.00002**	1.005	0.00009**	1.005
PSA when starting ARAT	0.000	0.000	0.219	1.000	0.640	1.000

Abbreviations: ADT = androgen deprivation therapy; ARAT = androgen receptor‐axis‐targeted therapies; BMI = Body Mass Index; ECOG = Eastern Cooperative Oncology Group; ISUP = International Society of Urological Pathology; PSA = prostate‐specific antigen.

^* p < 0.05.

^** p < 0.01.