Table 2.
Prognostic factors | Group with and without prognostic factor | Alive | Dead | P value |
---|---|---|---|---|
Type of IFI* | IA:14 | 7 | 7 | 0.573 |
Fongemia:13 | 7 | 6 | ||
Sex | Male:14 | 6 | 8 | 0.043 |
Female:15 | 9 | 6 | ||
Age | <65 years: 28 | 15 | 13 | 0.19 |
≥65 years: 1 | 0 | 1 | ||
Hemopathy | AML: 16 | 9 | 7 | 0.265 |
ALL: 6 | 4 | 2 | ||
Lymphoma: 3 | 1 | 2 | ||
Medullary aplasia: 3 | 0 | 3 | ||
Multiple myeloma: 1 | 1 | 0 | ||
Disease status | Complete remission: 6 | 4 | 2 | 0.038 |
Partial remission: 3 | 3 | 0 | ||
Relapse/progression: 12 | 3 | 9 | ||
Active disease: 8 | 5 | 3 | ||
Neutropenia | Yes: 27 | 13 | 14 | 0.259 |
No: 2 | 2 | 0 | ||
Depth of neutropenia | <500: 16 | 7 | 9 | 0.358 |
500-1000: 1 | 1 | 0 | ||
>1000: 1 | 0 | 1 | ||
Duration of neutropenia | ≥3 weeks: Yes: 9 | 2 | 7 | 0.041 |
No: 9 | 6 | 3 | ||
Broad-spectrum Antibiotic therapy | Yes: 17 | 8 | 9 | 0.5 |
No: 9 | 5 | 4 | ||
Parenteral nutrition | Yes: 12 | 5 | 7 | 0.297 |
No: 17 | 10 | 7 | ||
Corticosteroid therapy | Yes: 8 | 6 | 2 | 0.155 |
No: 20 | 9 | 11 | ||
Renal failure | Yes: 4 | 15 | 10 | 0.042 |
No: 25 | 0 | 4 | ||
Extended stay in the hematology department | Yes: 20 | 9 | 11 | 0.25 |
No: 9 | 6 | 3 | ||
Central venous catheter | Yes: 11 | 6 | 5 | 0.558 |
No: 18 | 9 | 9 | ||
Prophylactic antifungal treatment | Yes: 9 | 3 | 6 | 0.048 |
No: 17 | 10 | 7 | ||
Time to start antifungal treatment (days) | Average for living: 0.67 | 15 | - | 0.016 |
Average among decedents: 2.07 | - | 14 | ||
Thrombocytopenia | Yes: 22 | 11 | 11 | 0.4 |
No: 6 | 4 | 2 | ||
Lactate level (mmol/l) | Average for living: 1.67 | 10 | - | 0.035 |
Average among decedents:3.14 | - | 14 | ||
Procalcitonin level (ng/ml) | Average for living:5.30 | 10 | - | 0.043 |
Average among decedents:7.79 | - | 13 | ||
Fibrinogen level (g/l) | Average for living:3.46 | 8 | - | 0.048 |
Average among decedents:4.23 | - | 11 |
For the type of IFIs, neuromeningeal cryptococcosis and pulmonary mucormycosis were excluded from the list to avoid biasing the calculation.