Fig. 6.

NGF signaling is required for tactile sensation. (a) Scheme depicting dermal injection of NGF or PBS (Veh) into the right hind paw and experimental schedule. (b) Fine tactile sensitivity was examined with von Frey filaments whose mechanical pressure ranged from 0.008 g to 1 g, in NGF-injected mice and PBS-injected mice. 0.16g; p = 0.048, 0.6g; p = 0.029. (c) mRNA expression levels for mechanosensory factors in DRG of mice at 20 h after NGF or PBS injection (Veh: n = 14; NGF: n = 15). Trpv1; p = 0.054, Trpa1; p = 0.035, Trpc1; p = 0.028.*p < 0.05. Results are represented as mean ± SEM. Statistical analyses were performed using the Student’s t-test (b) or Welch’s t-test (c).