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. 2024 Nov 8;14:27192. doi: 10.1038/s41598-024-78683-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 7 — Dull phenotype of tactile sensitivity is rescued by intradermal injection of NGF. (a) Fine tactile sensitivity was examined with von Frey filaments whose mechanical pressure ranged from 0.008 g to 1 g, in Snx25^+/- mice and in Snx25^+/- mice at 24 h after NGF injection (n = 5). 0.07g; p = 0.012, 0.16g; p = 0.004, 0.4g; p = 0.032, 0.6g; p = 0.002, 1.0g; p = 0.001. (b) Changes of percent of withdrawal on the side injected with NGF of each Snx25^+/- mouse (n = 5). 0.16g; p = 0.004, 0.6g; p = 0.002, 1.0g; p = 0.001. (c) Fine tactile sensitivity was examined with von Frey filaments as above, in Snx25 mcKO mice and in Snx25 mcKO mice at 24 h after NGF injection (n = 4). 0.02g; p = 0.017, 0.04g; p = 0.017, 0.16g; p = 6.14e-05, 0.4g; p = 0.001, 0.6g; p = 0.015, 1.0g; p = 0.022. (d) Changes of percent of withdrawal on the side injected with NGF of each Snx25 mcKO mouse (n = 4). 0.04g; p = 0.017, 0.16g; p = 6.14e-05, 0.6g; p = 0.015, 1.0g; p = 0.022.*p < 0.05, **p < 0.01. Results are represented as mean ± SEM. Statistical analyses were performed using the Student’s t-test (Snx25^+/- vs Snx25^+/- + NGF, or Snx25 mcKO vs Snx25 mcKO + NGF).