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. 2024 Nov 9;15:9699. doi: 10.1038/s41467-024-53954-3

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Schematic overview of the analysis. Created in BioRender. Nelander, S. (2023) BioRender.com/b96y619. b Middle panel is the regulatory table from scregclust, with modules as columns and regulators (TFs) as rows. Top panel are annotation bars indicating what type and study each module originate from. Meta-modules (Fig. 5) are indicated by color in the bar below the middle panel. For ease of reading, two regulator (gene) names are indicated per row, the gene name after the comma are for the row below. Bottom panel display similarity of each module (Jaccard index) to a database of neuro-oncology related gene sets, derived from studies indicated by PubMed ID (PMID). Abbreviations: CT cellular tumor, MVP microvascular proliferation, GPM glycolytic/plurimetabolic, pan pseudopalisading cells around necrosis, NPC neural progenitor cells, PPR proliferating progenitor cells, IT infiltrative tumor, OPC oligodendrocyte progenitor cells, tRG truncated radial glia. Source data are provided as a Source Data file.