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. 2024 Nov 8;15:9679. doi: 10.1038/s41467-024-53975-y

Fig. 5. Enantiomeric Lipid Diets Negatively Affect Cell Growth and Membrane Properties.

Fig. 5

a Enantiomeric (ent) POPC is a synthetic chiral POPC with the head group in the sn-1 position, rather than sn-3 position. b M. mycoides and c JCVI-Syn3A cells exhibit slower growth when grown on diets with entPOPC present; are more fragile to hypoosmotic shock when grown on diets with entPOPC present; and are more permeable to non-chiral fluorescein diacetate (FDA) when grown on diets with entPOPC present. d M. mycoides and e JCVI-Syn3A cell growth and membrane permeability are inversely correlated. P-values, calculated using a two-tailed Student’s t-test, are shown when relevant. N, number of replicates for all growth rates, can be found in Supplementary Data S1. N = 3 biological replicates for osmotic sensitivity and permeability subfigures.