Figure 1.

Management of local or locoregional UKP-NENs. Purple: algorithm title; orange: surgery; turquoise: non-systemic anticancer therapies or combination of treatment modalities; white: other aspects of management and non-treatment aspects. ChT, chemotherapy; CPG, Clinical Practice Guideline; MTC, medullary thyroid cancer; NEC, neuroendocrine carcinoma; NEN, neuroendocrine neoplasm; NET, neuroendocrine tumour; PCC–PGL, pheochromocytoma–paraganglioma; RT, radiotherapy; UKP, unknown primary. ^aFour cycles of platinum–etoposide.