Figure 5.

Management of carcinoid syndrome and Cushing syndrome induced by UKP-, GUGy- or HN-NENs. Purple: algorithm title; orange: surgery; dark green: RT; blue: systemic anticancer therapy or their combination; turquoise: non-systemic anticancer therapies or combination of treatment modalities; white: other aspects of management and non-treatment aspects. GUGy, genitourinary or gynaecological; HN, head and neck; IFN-α, interferon-α; NEN, neuroendocrine neoplasm; PRRT, peptide receptor radionuclide therapy; SSA, somatostatin analogue; UKP, unknown primary.