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The influence of temperature on midazolam 1-hydroxylation by CYP3A4 variants.
(a) CYP3A4.1, (b) CYP3A4.2, (c) CYP3A4.7, (d) CYP3A4.16, (e) CYP3A4.18
The solid (open), dotted (closed), and dashed lines (gray symbols) represent 37 °C, 34 °C, and 40 °C, respectively.
Each symbol represents a mean ± S.D. value derived from five independent experiments.
