Table 2.
Clinical characteristics of M. smegmatis cases.
| Patient # (age/gender) | Clinically relevant (# isolates) | Site of infection (#isolates) | Hardware involved | Surgery? | Antibiotics | Treatment Duration | Clinical outcome | Immuno-suppression |
|---|---|---|---|---|---|---|---|---|
| 1 (75F) | No (1) | Pulmonary | NA | NA | NA | NA | NA | IgM deficiency * |
| 2 (60F) | Inad (1) | Pulmonary | NA | NA | NA | NA | NA | No |
| 3 (64F) | Yes (1) | Breast | Breast Tissue expander | Expander removed | TMP/SMX; doxycycline; moxifloxacin | 3 months | Resolved | SLE * |
| 4 (82F) | Yes (3) | Sternum | Sternal wires | Wire removal, debridement | TMP/SMX; doxycycline; moxifloxacin | 6 months | Resolved | No |
| 5 (54F) | Yes (1) | Right leg | No | No | Amikacin; Ciprofloxacin; minocycline 6 mo delay to treatment |
unknown | unknown | No |
| 6 (56F) | No (1) | Pulmonary | NA | NA | Rifampin, Isoniazid, Pyrazinamide, Ethambutol (RIPE therapy) | 6 months (for presumed TB) | NA | No |
| 7 (59 M) | Yes (1) | Right knee | TKA | 2-stage TKA replacement | Doxycycline and amikacin; ciprofloxacin, TMP/SMX; briefly with ethambutol Change from doxycycline and amikacin due to dizziness and vertigo; ethambutol was cost-prohibitive |
6 weeks | Resolved | No |
| 8 (35F) | Yes (1) | Leg | No | No | doxycycline; TMP/SMX | 3 months | Resolved | No |
| 9 (48F) | Yes (1) | Blood | PICC catheter | PICC removed | cefoxitin, ciprofloxacin, clarithromycin; ciprofloxacin, doxycycline, imipenem Change of therapy in response to susceptibilities |
1 month | Resolved | Breast cancer, LVAD * |
| 10 (79F) | No (1) | Pulmonary − BAL | NA | NA | NA | NA | NA | No |
| 11 (69F) | Yes (1) | Right elbow | Total elbow arthroplasty | Removal, spacer | Imipenem, vancomycin, doxycycline, TMP/SMX 4-drug induction for 6 weeks, 6-month consolidation with doxycycline and TMP/SMX |
6 months | Resolved | No |
| 12 (22F) | Yes (1) | Left thigh | No | Debridement | Imipenem, linezolid, doxycycline; imipenem stopped at discharge |
2 weeks | Resolved | No |
| 13 (70 M) | Yes (1) | Sternum | Sternal wires | Debridement | Imipenem, doxycycline, TMP/SMX | 8 months | Resolved | No |
Inad: inadequate clinical information available to determine impact.
LVAD: Left Ventricular Assist Device.
NA: not applicable.
TMP/SMX: Trimethoprim with Sulfamethoxazole.
* Relevant health history, Not prespecified immunocompromising condition.