Table 2.
Serum Prx4 levels and the risk of new-onset CKD in the general population.
| HR per doubling of serum Prx4 | T1 |
T2 |
T3 |
|
|---|---|---|---|---|
| <0.50 U/L | 0.50–0.87 U/L | >0.87 U/L | ||
| CKD (composite outcome) (n=867) | ||||
| Model 1 | 1.29 [1.21–1.37], p < 0.001 | 1.00 (reference) | 1.19 [0.99–1.43], p = 0.060 | 1.94 [1.64–2.29], p < 0.001 |
| Model 2 | 1.20 [1.12–1.28], p < 0.001 | 1.00 (reference) | 1.10 [0.92–1.32], p = 0.037 | 1.60 [1.36–1.90], p < 0.001 |
| Model 3 | 1.16 [1.09–1.24], p < 0.001 | 1.00 (reference) | 1.09 [0.91–1.31], p = 0.353 | 1.48 [1.25–1.76], p < 0.001 |
| Model 4 | 1.16 [1.08–1.24], p < 0.001 | 1.00 (reference) | 1.09 [0.91–1.32], p = 0.355 | 1.46 [1.22–1.74], p < 0.001 |
| CKD (eGFR <60 mL/min/1.73 m2) (n=229) | ||||
| Model 1 | 1.33 [1.20–1.47], p < 0.001 | 1.00 (reference) | 1.33 [0.96–1.84], p = 0.082 | 2.21 [1.64–2.96], p < 0.001 |
| Model 2 | 1.19 [1.06–1.33], p=0.003 | 1.00 (reference) | 1.18 [0.85–1.63], p = 0.317 | 1.56 [1.16–2.11], p=0.003 |
| Model 3 | 1.12 [1.00–1.27], p = 0.057 | 1.00 (reference) | 1.17 [0.84–1.61], p = 0.352 | 1.39 [1.02–1.88], p=0.036 |
| Model 4 | 1.10 [0.97–1.25], p = 0.127 | 1.00 (reference) | 1.12 [0.81–1.56], p = 0.500 | 1.33 [0.97–1.81], p = 0.077 |
| CKD (UAE >30 mg/24-h) (n=667) | ||||
| Model 1 | 1.29 [1.20–1.38], p < 0.001 | 1.00 (reference) | 1.21 [0.99–1.49], p = 0.068 | 1.95 [1.61–2.35], p < 0.001 |
| Model 2 | 1.21 [1.13–1.31], p < 0.001 | 1.00 (reference) | 1.13 [0.92–1.39], p = 0.235 | 1.67 [1.38–2.03], p < 0.001 |
| Model 3 | 1.20 [1.11–1.30], p < 0.001 | 1.00 (reference) | 1.12 [0.91–1.39], p = 0.269 | 1.60 [1.32–1.95], p < 0.001 |
| Model 4 | 1.19 [1.10–1.29], p < 0.001 | 1.00 (reference) | 1.24 [0.91–1.40], p = 0.268 | 1.58 [1.29–1.93], p < 0.001 |
Model 1, crude model. Model 2, model 1 with adjustment for age and sex. Model 3, model 2 with adjustment for current smoking, systolic blood pressure, chronic heart failure, diabetes, total cholesterol, use of lipid-lowering drugs. Model 4, model 3 with adjustment for high-sensitive C-reactive protein. Bold P-values indicate statistical significance. Abbreviations: HR, hazard ratio; CKD, chronic kidney disease; eGFR, estimated glomerular filtration rate; UAE, urinary albumin excretion.