Fig. 4.

2,3-BPG levels were altered in the alkalosis state. PaO₂ (A), %SaO₂ (B), hemoglobin (C), and 2,3-BPG (D) levels in patients without acid-base imbalance and with metabolic and respiratory alkalosis. Patients were classified by pH and PaCO₂ levels. The PaO₂ was obtained by emo-gas analysis, while SaO₂ by the oximeter. 2,3-BPG levels were assessed by specific immunoenzymatic assays in RBCs of COVID-19 patients and reported here expressed as nmol/mL. Data are reported as mean ± SD. Differences between groups were evaluated by One-Way ANOVA non-parametric test (Kruskal-Wallis test): ∗ p < 0.05; ∗∗p < 0.01 vs. metabolic alkalosis group. GraphPad Prism 8 was used to create the figure.